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通过扫描电镜和能谱仪同步检测胆囊粘膜、胆石和鲕石的超微结构、金属元素及其氧化物,观察胆石核心的细菌及胆囊收缩素对异形胆囊的收缩效应,探索肝胆功能、肝胆疾病和胆石症的关系。综合研究结果提出:胆石形成的启动因素是肝胆系统的感染与炎症;胆石形成的基本条件是肝胆系统整合和自稳态生理调节的紊乱;胆石结构形成是胆道内胆汁理化力学作用的结果:“肝胆同治”是胆石症的防治原则。
The ultrastructures of gallbladder mucosa, gallstone and oolite, metal elements and their oxides were simultaneously detected by scanning electron microscopy and energy dispersive spectroscopy. The contractile effect of gallstone core bacteria and cholecystokinin on abnormal gallbladder was observed. The hepatobiliary function, hepatobiliary disease And cholelithiasis relationship. The results of the comprehensive study suggest that the initiating factor of gallstone formation is the infection and inflammation of hepatobiliary system; the basic conditions of gallstone formation are the integration of hepatobiliary system and the disorder of self-homeostasis; the formation of gallstone structure is the result of the physicochemical and biliary function of bile duct: “Hepatobiliary Tongzhi” is the prevention and treatment of cholelithiasis.