论文部分内容阅读
目的:研究气体信号分子与胚胎停育的相关性,并确定剂量反应关系,以提供作为胚胎停育筛查的标志物。方法:选择对照组、病例组各90例,采用ELISA方法测定血浆中NO、CO和H2S的浓度。结果:在正常妊娠和胚胎停育的孕妇外周血中均可检测到内源性气体信号分子NO、CO、H2S的存在。NO、CO和H2S在病例组中浓度显著低于对照组(P<0.05)。对照组血浆NO、CO与H2S浓度之间存在相关关系,经统计学分析得出,NO和H2S、CO和H2S之间呈正相关,而NO和CO之间无相关性;病例组血浆NO、CO与H2S浓度之间无相关关系。结论:NO、CO和H2S浓度降低是导致胚胎停育的重要因素。血浆中NO和CO浓度增加的同时,H2S浓度也会相应的增加,这对胚胎的正常发育具有积极的保护作用。
PURPOSE: To study the association of gas signaling molecules with embryo shutdowns and to determine the dose-response relationship to provide a marker of embryo suspension screening. Methods: Ninety control subjects and 90 control subjects were enrolled in this study. Plasma concentrations of NO, CO and H2S were measured by ELISA. Results: The endogenous gas signal molecules NO, CO and H2S were detected in the peripheral blood of normal pregnant and embryo-off pregnant women. The concentrations of NO, CO and H2S in the case group were significantly lower than those in the control group (P <0.05). There was a positive correlation between NO and H2S, CO and H2S in the control group, and there was no correlation between NO and CO in the plasma. NO, CO No correlation with H2S concentration. Conclusion: The decrease of NO, CO and H 2 S concentration are the important factors that lead to the suspension of embryos. While the concentration of NO and CO in plasma increases, the concentration of H2S will also increase correspondingly, which has a positive protective effect on the normal development of embryos.