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本文将22只家兔随机分为三组。喂饲胆固醇诱发高脂血症。实验组给予疏水性表面活性剂Soluchorol,探讨其对高脂血症及动脉硬化的预防作用。结果表明,实验组血清总胆固醇及低密度脂蛋白均明显低于高脂组(P<0.01)。血清过氧化脂质亦低于高脂组(P<0.05)。二组主动脉斑块面积及厚度的对比分析均有显著性差异。提示疏水性表面活性剂具有一定的降血脂及预防动脉硬化的作用。但对Soluchorol的合成过程及其在机体内的代谢过程,使用剂量及毒性,试验等方面尚需进一步研究。
In this paper, 22 rabbits were randomly divided into three groups. Feeding cholesterol induces hyperlipidemia. The experimental group was given the hydrophobic surfactant Souchorol to explore its preventive effect on hyperlipidemia and arteriosclerosis. The results showed that serum total cholesterol and low-density lipoprotein in the experimental group were significantly lower than those in the high-fat group (P<0.01). Serum lipid peroxide was also lower than that of high-fat group (P<0.05). There was a significant difference between the two groups of aortic plaque area and thickness. It is suggested that the hydrophobic surfactant has a certain effect of lowering blood fat and preventing arteriosclerosis. However, further studies are needed on the synthesis and the metabolism of Soluchorol, its use of doses and toxicity, and tests.