缺血再灌注损伤(ischem ia-reperfusion in jury,IR I)是临床常见的病理过程,其发生发展过程涉及到自由基、钙超载、白细胞的呼吸爆发等损伤作用。长期以来主要围绕以上几个方面进行对IR损伤的防治。褪黑激素(m elaton in,MEL)是由松果体分泌的一种吲哚类激素,能够增强机体多个系统功能,近年来研究发现其通过抗氧化以及在分子水平发挥抗器官IR损伤作用。 Ischemia-reperfusion injury (IRI) is a common clinical pathological process, the occurrence and development of which involve free radicals, calcium overload, respiratory burst of leukocytes and other injuries. For a long time mainly around the above aspects of prevention and treatment of IR damage. Melatonin (MEL), an indole hormone secreted by the pineal gland, can enhance multiple system functions of the body. In recent years, it has been reported that MEL plays an anti-oxidant and anti-IR role at the molecular level .