Highly efficient Co3O4/TiO2 monolithic catalysts with enhanced stability were in-situ grown on Ti mesh for CO oxidation, which could completely oxidize CO at 120 C. The comprehensive catalytic performance is competitive to some noble metal catalysts and conventional Co3O4 powder catalysts, which holds great potential toward industrial applications. Meanwhile, the in-situ synthesis strategy of Co3O4/TiO2 monolithic catalysts on flexible mesh substrate in this work can be extended to the development of a variety of oxide-based monolithic catalysts towards diverse catalysis applications.