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作者对可乐定抗溃疡性结肠炎(UC)的作用进行了双盲试验。方法:45名重度UC患者,其中男性20名、女性25名,年龄17～51岁,病程1～23年。将病人随机分为3组,每组15人。全程试验30周,分为5期,每期6周。其中Ⅰ、Ⅲ、Ⅴ期为药物治疗期,病人随机分别服用强的松20mg,每日3次,柳氮磺吡啶1.5mg,每日3次或可乐定0.3 mg,每日3次;Ⅱ、Ⅳ期为安慰剂对照期。在Ⅰ、Ⅲ、Ⅴ治疗期末的12天中,强的松剂量每天递减2.5mg直至停
The authors conducted a double-blind trial of the effect of clonidine on ulcerative colitis (UC). Methods: Forty-five patients with severe UC, including 20 males and 25 females, aged from 17 to 51 years with a duration of 1 to 23 years. The patients were randomly divided into 3 groups of 15 people each. The whole experiment for 30 weeks, divided into 5 periods of 6 weeks. The patients were randomized to receive 20 mg prednisone 3 times daily, sulfasalazine 1.5 mg, 3 times daily or clonidine 0.3 mg three times daily. Phase IV placebo control period. In the 12 days after the end of treatment Ⅰ, Ⅲ and Ⅴ, the dosage of prednisone decreased 2.5mg daily until stop