论文部分内容阅读
目的对比不同方法治疗他巴唑致粒细胞缺乏症的疗效,以指导临床治疗。方法 15例他巴唑(MMI)致粒细胞缺乏症患者,所有病例均停用他巴唑。病例随机分为3组,采用不同的治疗方案,A组:5例,采用普通治疗;B组:5例,采用普通治疗加用糖皮质激素(强的松30mg/d);C组:5例,在普通治疗基础上加用重组人粒细胞集落刺激因子(rhG-CSF),300μg/d皮下注射。以上各组每日复查血常规,观察中性粒细胞恢复到>2.0×109/L的时间。结果 A、B、C组中性粒细胞数恢复正常时间分别为(12.8±0.4)d、(12.6±0.5)d、(6.4±0.5)d,B组与A组比较差异无统计学意义。C组与A、B组比较差异有统计学意义(P<0.001)。结论糖皮质激素在MMI导致粒细胞缺乏症治疗中可能是无效的;rhG-CSF在MMI致粒细胞缺乏症治疗中是最有效的。
Objective To compare the curative effect of different methods for the treatment of tacrolimus granulocytic deficiency in order to guide the clinical treatment. Methods Fifteen patients with MMI granulocytopenia were enrolled. Metarbazole was discontinued in all cases. The patients were randomly divided into 3 groups with different treatment regimens. Group A: 5 patients received general treatment; Group B: 5 patients received general treatment plus glucocorticoid (prednisone 30 mg / d); Group C: 5 For example, add recombinant human granulocyte colony-stimulating factor (rhG-CSF) on the basis of ordinary treatment, 300μg / d subcutaneous injection. The above groups daily review of blood routine observation of neutrophils recovered to> 2.0 × 109 / L of time. Results The numbers of neutrophils recovered in groups A, B and C were (12.8 ± 0.4) days, (12.6 ± 0.5) days and (6.4 ± 0.5) days, respectively. There was no significant difference between group B and group A. The difference between group C and group A and group B was statistically significant (P <0.001). Conclusions Glucocorticoids may be ineffective in the treatment of agranulocytosis due to MMI; rhG-CSF is most effective in the treatment of MMI-induced neutropenia.