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cystatin SN是半胱氨酸蛋白酶抑制剂超家族的新成员,在肿瘤的侵袭转移、细胞凋亡等病理生理过程中发挥重要的作用。cystatin SN基因的表达可以影响胃肠道肿瘤组织的生物学恶性潜能,促进肿瘤的生长、侵袭和转移;而且cystatin SN转录、表达水平的高低与胃肠道肿瘤的预后呈正相关,可望成为胃肠道恶性肿瘤预后的肿瘤标志物。该文就cystatin SN的生物学特性及其在胃肠道肿瘤发生、发展中的作用研究进展予以综述。
Cystatin SN is a new member of the cystatin superfamily and plays an important role in pathophysiological processes such as tumor invasion and metastasis and apoptosis. The expression of cystatin SN gene can affect the biological malignant potential of gastrointestinal cancer tissue and promote the growth, invasion and metastasis of the tumor. Moreover, the expression of cystatin SN is positively correlated with the prognosis of gastrointestinal cancer and is expected to become the stomach Prognosis of intestinal malignancies tumor markers. This review summarizes the biological characteristics of cystatin SN and its role in the development and progression of gastrointestinal tumors.