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目的:研究温州地区汉族人群ApoB基因7673多态性和分布情况。方法:采用聚合酶链式反应和测序方法,对304例正常人群ApoB基因7673位点进行多态性分析。结果:温州地区汉族人群的ApoB基因具有C7673T多态性,CC和CT基因型分别是93.42%和6.58%,未发现TT基因型,C和T等位基因频率分别是96.71%和3.29%。结论:温州地区汉族人群ApoB基因C7673T具有多态性,T等位基因频率明显低于欧美白人,与文献报道的其他地区汉族人群分布情况相近。T等位基因分布频率没有性别差异。
Objective: To study the polymorphism and distribution of ApoB gene 7673 in Han population in Wenzhou area. Methods: Polymerase chain reaction and sequencing were used to analyze the polymorphism of ApoB gene 7673 in 304 normal subjects. Results: The ApoB gene of Han population in Wenzhou had C7673T polymorphism. The CC and CT genotypes were 93.42% and 6.58% respectively. No TT genotype was found. The frequencies of C and T alleles were 96.71% and 3.29%, respectively. CONCLUSION: ApoB gene C7673T is polymorphic in Han population in Wenzhou, and the frequency of T allele is significantly lower than that of white people in Europe and the United States, which is similar to the distribution of Han population in other areas of the country. There is no gender difference in T allele frequencies.