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目的探讨CyclinD1、Cdk4在子宫内膜癌中的表达与意义。方法应用免疫组织化学,检测20例正常子宫内膜及20例不典型增生子宫内膜和40例子宫内膜癌中的CyclinD1与Cdk4蛋白的表达情况。结果 CyclinD1与Cdk4的阳性表达在正常子宫内膜、不典型增生子宫内膜和子宫内膜癌中依次增加,组间差异具有统计学意义(P<0.05),与子宫内膜癌的分化程度,Dukes分期及淋巴结转移呈正相关关系(P<0.05)。结论 CyclinD1与Cdk4蛋白的过度表达可能在子宫内膜癌的发生、发展、浸润及转移中起重要作用,对判断子宫内膜癌的恶性程度具有一定的临床意义,还可能作为一种有价值的肿瘤标志物。
Objective To investigate the expression and significance of CyclinD1 and Cdk4 in endometrial carcinoma. Methods Immunohistochemistry was used to detect the expression of CyclinD1 and Cdk4 in 20 cases of normal endometrium, 20 cases of atypical hyperplasia and 40 cases of endometrial carcinoma. Results The positive expressions of CyclinD1 and Cdk4 in normal endometrium, atypical hyperplasia endometrium and endometrial carcinoma increased in turn, the difference was statistically significant (P <0.05), with the differentiation of endometrial carcinoma, Dukes staging and lymph node metastasis were positively correlated (P <0.05). Conclusion The overexpression of CyclinD1 and Cdk4 may play an important role in the carcinogenesis, progression, invasion and metastasis of endometrial carcinoma. It is of clinical significance for judging the malignancy of endometrial carcinoma and may also serve as a valuable Tumor markers.