论文部分内容阅读
目的探讨115例药物性肝炎患者的病因、临床表现、治疗和预后,以提高对该病的认识。方法采用回顾性分析法对115例药物性肝炎住院患者的用药史、临床表现、肝功能检查、病原学标志以及治疗转归做出综合分析。结果引起肝损害的药物种类繁多,以中药为最多,占(21.74%),其次为抗结核药(17.39%),解热镇痛类药物(13.91%),抗生素药物(13.04%);临床类型为肝细胞型多见占53.9%。胆汁淤积型占23.5%。混合型占17.54%;主要临床表现有纳差、乏力、黄疸、恶心、呕吐等;多数患者预后较好。结论可引起药物性肝损害的药物种类繁多,其临床表现和实验室检查缺乏特异性;严格把握用药指征,注意监测肝功能是有效的预防措施。
Objective To investigate the etiology, clinical manifestations, treatment and prognosis of 115 patients with drug-induced hepatitis to improve their understanding of the disease. Methods A retrospective analysis of 115 cases of drug-induced hepatitis inpatients medication history, clinical manifestations, liver function tests, pathogenic markers and treatment outcome to make a comprehensive analysis. Results The variety of drugs that caused liver damage was the largest, accounting for 21.74%, followed by anti-TB drugs (17.39%), antipyretic and analgesic drugs (13.91%) and antibiotics drugs (13.04%). The clinical types More common for hepatocellular type accounted for 53.9%. Cholestasis accounted for 23.5%. Mixed accounted for 17.54%; the main clinical manifestations of anorexia, fatigue, jaundice, nausea, vomiting; most patients with better prognosis. Conclusions A wide range of drugs can cause drug-induced liver damage, the clinical manifestations and laboratory tests lack specificity; strict indications for medication, attention to monitoring of liver function is an effective preventive measure.