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近年来,白色念珠菌导致的感染发病率逐年上升,已严重威胁人们健康。在临床上,最常用的唑类抗真菌药物因长期广泛使用,导致致病真菌耐药性逐年增加。文章综述白色念珠菌对唑类药物耐药机制的研究进展,为合理应用唑类药物和开发新型药物提供理论依据。
In recent years, the incidence of Candida albicans infection increased year by year, has seriously threatened people’s health. Clinically, the most commonly used azole antifungal agents are widely used over a long period of time, leading to increased annual resistance of pathogenic fungi. This review summarizes the research progress of Candida albicans on the mechanism of resistance to azoles and provides a theoretical basis for the rational application of azole drugs and the development of new drugs.