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激活蛋白-1(activator protein-1,AP-1)是细胞内一类转录激活因子,主要由原癌基因编码的蛋白质Jun和Fos组成,以同源或异源二聚体复合物形式结合DNA靶序列,调控靶基因表达。AP-1通过调节靶基因表达来应对多种刺激(包括细胞因子、生长因子、压力及细菌和病毒感染等)对细胞的影响,参与调节细胞增殖、分化、凋亡以及炎症等多种细胞过程。该文就AP-1的结构特点、生物学功能、活性调控及其在医学研究中的应用作一综述。
Activator protein-1 (AP-1) is a type of intracellular activator of transcription. It mainly consists of Jun and Fos proteins encoded by oncogenes and binds to DNA as homologous or heterodimer complexes Target sequence, regulating target gene expression. AP-1 regulates the cellular effects of various stimuli (including cytokines, growth factors, stress and bacterial and viral infections) by regulating target gene expression and is involved in the regulation of many cellular processes such as cell proliferation, differentiation, apoptosis and inflammation . This review summarizes the structural features, biological functions, activity regulation and the application of AP-1 in medical research.