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目的 :对Ⅳ型胶原 (CollagentypeⅣ ,CⅣ )、层粘蛋白 (Laminin ,LN)在胃癌组织中的表达进行量化分析。方法 :放射免疫分析测定 2 3例胃癌患者手术切除的胃肿瘤组织和正常组织匀浆及外周静脉血CⅣ、LN含量 ,分析它们之间的关系。结果 :胃癌组织组CⅣ含量高于正常胃组织组 (p <0 0 0 1) ,并且与外周血血清CⅣ含量呈正相关 (r=0 5 6 ,p <0 0 1)。结论 :胃癌患者的胃组织和血清CⅣ含量改变与胃肿瘤的恶性程度密切相关。目的 :对Ⅳ型胶原 (CollagentypeⅣ ,CⅣ )、层粘蛋白 (Laminin ,LN)在胃癌组织中的表达进行量化分析。方法 :放射免疫分析测定 2 3例胃癌患者手术切除的胃肿瘤组织和正常组织匀浆及外周静脉血CⅣ、LN含量 ,分析它们之间的关系。结果 :胃癌组织组CⅣ含量高于正常胃组织组 (p <0 0 0 1) ,并且与外周血血清CⅣ含量呈正相关 (r=0 5 6 ,p <0 0 1)。结论 :胃癌患者的胃组织和血清CⅣ含量改变与胃肿瘤的恶性程度密切相关。
OBJECTIVE: To quantitatively analyze the expression of collagen type Ⅳ (CⅣ) and laminin (LN) in gastric cancer. Methods: Radioimmunoassay was used to measure the content of CⅣ and LN in the resected gastric tumor tissues, normal tissue homogenates and peripheral venous blood in 23 gastric cancer patients and to analyze the relationship between them. Results: The level of CⅣ in gastric cancer tissue was higher than that in normal gastric tissue (p <0.01), and positively correlated with serum CⅣ level in peripheral blood (r = 0 56, p 0 01). Conclusion: The gastric tissue and serum CⅣ levels in patients with gastric cancer are closely related to the malignant degree of gastric cancer. OBJECTIVE: To quantitatively analyze the expression of collagen type Ⅳ (CⅣ) and laminin (LN) in gastric cancer. Methods: Radioimmunoassay was used to measure the content of CⅣ and LN in the resected gastric tumor tissues, normal tissue homogenates and peripheral venous blood in 23 gastric cancer patients and to analyze the relationship between them. Results: The level of CⅣ in gastric cancer tissue was higher than that in normal gastric tissue (p <0.01), and positively correlated with serum CⅣ level in peripheral blood (r = 0 56, p 0 01). Conclusion: The gastric tissue and serum CⅣ levels in patients with gastric cancer are closely related to the malignant degree of gastric cancer.