论文部分内容阅读
目的:本文旨在研究尼莫地平对尼古丁诱发的大鼠烟碱样作用(N样作用)是否有缓解效果。方法:雄性大鼠随机分为A、B两组。A组只给与尼古丁5mg/kg激发N样作用,B组通过静脉注射先给与尼莫地平注射液3mg/kg,30min后再给予尼古丁5mg/kg激发,对比用药前后大鼠N样作用的持续时间的变化。结果:实验表明提前给予尼莫地平能有效的减少了大鼠N样作用的持续时间。该实验的结果将为尼古丁成瘾的戒断提供一定的帮助。
Aims: This study aimed to investigate whether nimodipine has a beneficial effect on nicotine-induced nicotine-like (N-like) effects in rats. Methods: Male rats were randomly divided into A and B groups. Group A only given nicotine 5mg / kg to stimulate the N-like effect, Group B intravenously administered with nimodipine injection 3mg / kg, 30min and then given nicotine 5mg / kg challenge compared with the drug before and after N-like effect Changes in duration. RESULTS: Experiments showed that pretreatment with nimodipine effectively reduced the duration of N-like effect in rats. The results of this experiment will provide some help for the withdrawal of nicotine addiction.