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目的 本文旨在探讨蛛网膜下腔出血 (SAH )患者不同时段血浆内皮素Ⅰ (ETⅠ)、血管紧张素Ⅱ (ATⅡ)及一氧化氮 (NO)的变化规律及其与脑血管痉挛之间的关系。方法 测定SAH患者不同时段ETⅠ 、ATⅡ 及NO的含量。结果 SAH患者发病 2 4小时内ETⅠ 、ATⅡ 、NO即开始升高达最高水平 ,并持续达 3～ 4天 ;ETⅠ、ATⅡ 一周后开始下降 ,但直到两周后仍明显高于正常对照组。NO一周后即降至正常。结论 ETⅠ 、ATⅡ 、NO在SAH后的脑血管痉挛中起着十分重要的作用
Objective This article aims to investigate the changes of plasma endothelin (ETⅠ), angiotensin Ⅱ (ATⅡ) and nitric oxide (NO) in patients with subarachnoid hemorrhage (SAH) at different time points and its relationship with cerebral vasospasm relationship. Methods The contents of ET Ⅰ, AT Ⅱ and NO in different time periods of SAH patients were determined. Results The levels of ETⅠ, ATⅡ and NO began to increase to the highest level within 3-4 hours after the onset of SAH. The levels of ETⅠ and ATⅡ began to decrease after one week, but remained significantly higher than those of the normal control group until two weeks later. NO to normal after a week. Conclusions ETⅠ, ATⅡ, NO plays an important role in cerebral vasospasm after SAH