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目的探讨EB病毒相关抗体和抗原联合检测在鼻咽癌临床诊断中的价值。方法采集2014年9月至2015年10月某医学检验机构存档的126例鼻咽癌患者的EB病毒检测报告,将此126例患者作为研究组,随机选取126例同期体检者作为健康对照组,采集静脉血进行VCA/IgA、EA/IgA抗体及EB病毒DNA(EBV-DNA)三项指标进行间接荧光免疫法检测,统计对比两组抗体抗原相关指标阳性率。结果研究组VCA/IgA、EA/IgA、EBV-DNA三项指标检测阳性率与对照组比较存在显著统计学差异(P<0.05),单独检测时VCA/IgA敏感度最高,联合检测时阳性率为97.6%(123/126),检测阳性率明显高于任一指标单独检测阳性率(P<0.05)。结论 EB病毒抗体抗原联合检测可显著提高鼻咽癌诊断敏感性,对提高早期检出率具有重要意义。
Objective To investigate the value of combined detection of Epstein-Barr virus-related antibodies and antigens in the clinical diagnosis of nasopharyngeal carcinoma. Methods A total of 126 cases of nasopharyngeal carcinoma (EBV) were enrolled in a medical examination institution from September 2014 to October 2015. The 126 patients were selected as the study group, 126 cases of the same period were randomly selected as the healthy control group, The venous blood samples were collected for VCA / IgA, EA / IgA antibody and Epstein-Barr virus DNA (EBV-DNA) for indirect immunofluorescence assay. The positive rates of antibody-antigen-related markers were compared between the two groups. Results The positive rates of VCA / IgA, EA / IgA and EBV-DNA in the study group were significantly different from those in the control group (P <0.05). The sensitivity of VCA / IgA in the test group was the highest Was 97.6% (123/126). The detection positive rate was significantly higher than that of any single test (P <0.05). Conclusion The combined detection of Epstein-Barr virus antibody antigen can significantly improve the diagnostic sensitivity of nasopharyngeal carcinoma, which is of great significance to improve the early detection rate.