氧氟沙星为喹诺酮类合成新型抗菌药物。自１９９３年４至１１月，我科应用国内研制的０．３％氧氟沙星滴眼液治疗急性细菌性结膜炎５２例、细菌性角膜炎３１例，同时用０．３％诺氟沙星滴眼液设置对照组。治疗组两种疾病的痊愈率分别为９８．１％及７７．４％，有效率分别为１００％及９６．８％，与对照组比较无显著差异性。在本组培养的菌株中，对氧氟沙星及诺氟沙星敏感的比率分别为９７％及８９．５％，二者差异有显著性。最低抑菌浓度测定显示前者具有更高的抗菌活性。不良反应仅为个别患者轻微一过性刺激症状。因此建议推广使用。 Ofloxacin for quinolone synthesis of new antibacterial drugs. From April to November 1993, our department applied 0.3% of ofloxacin eye drops developed in China for the treatment of 52 cases of acute bacterial conjunctivitis, 31 cases of bacterial keratitis, while 0.3% norfloxacin Star drops set the control group. In the treatment group, the cure rates of the two diseases were 98.1% and 77.4%, respectively, and the effective rates were 100% and 96.8% respectively, which showed no significant difference compared with the control group. Among the strains cultured in this group, the sensitive rates of ofloxacin and norfloxacin were 97% and 89.5%, respectively, with significant difference between the two groups. The minimum inhibitory concentration assay showed that the former has higher antibacterial activity. Adverse reactions are slight transient irritation symptoms for individual patients. Therefore recommended to promote the use of.