不同体重多囊卵巢综合征患者的内分泌和代谢特点

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目的:比较超重组与正常体重组多囊卵巢综合征(PCOS)患者内分泌和代谢特点的差异,对临床实施针对性治疗提供帮助。方法:按照体重指数23 kg/m2为界限,将多囊卵巢综合征患者分为超重组(34例)和正常体重组(59例),检测患者血清基础性激素、血糖及胰岛素的水平,并对两组的内分泌和代谢相关指标做对比。结果:超重组与正常体重组PCOS患者的性激素基础值对比,FSH、PRL、E2、T值无显著差异(P>0.05),LH值超重组明显低于正常体重组(P<0.05)。空腹血糖和餐后2 h血糖两组对比无明显差异(P>0.05),空腹胰岛素和餐后2 h胰岛素水平超重组明显高于正常体重组(P<0.05)。超重组空腹G IR比值、IAI明显低于正常体重组,HOMA超重组明显高于正常体重组,有统计学意义(P<0.05),2 h G/I比值,两组统计学上对比无明显差异(P>0.05)。结论:PCOS的临床表现及生化改变具有高度异质性,超重的PCOS患者高胰岛素及胰岛素抵抗明显比正常体重组严重,降低体重对于改善其胰岛素抵抗状态是有意义的,对于正常体重的PCOS患者,高LH是其常见的表现及特征。 Objective: To compare the difference of endocrine and metabolic characteristics between overweight and normal weight group patients with polycystic ovary syndrome (PCOS), and to provide some help for the targeted clinical treatment. Methods: According to the body mass index of 23 kg / m2, the patients with polycystic ovary syndrome were divided into overweight group (n = 34) and normal weight group (n = 59). The levels of serum basic hormones, blood glucose and insulin were measured. The two groups of endocrine and metabolic related indicators to do. Results: There was no significant difference in FSH, PRL, E2, T between the overweight group and the normal weight group (P> 0.05). LH overweight group was significantly lower than that of the normal weight group (P <0.05). There was no significant difference between fasting blood glucose and 2 h postprandial blood glucose (P> 0.05). Fasting insulin and 2 h postprandial insulin levels in overweight group were significantly higher than those in normal weight group (P <0.05). The ratio of fasting GIR in overweight group was significantly lower than that in normal weight group (P <0.05), while the IAI in HOMA overweight group was significantly higher than that in normal weight group (P <0.05). There was no significant difference between the two groups Difference (P> 0.05). CONCLUSIONS: The clinical manifestations and biochemical changes of PCOS are highly heterogeneous. Hyperinsulinemia and insulin resistance in overweight patients with PCOS are significantly more severe than those in normal weight groups. It is significant to reduce body weight to improve their insulin resistance status. For PCOS patients with normal body weight , High LH is its common performance and characteristics.
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