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基因组的完整和稳定是机体生存的基础,基因组异常导致肿瘤、免疫缺陷等多种疾病。DNA损伤修复是维持核基因组完整和稳定的首要机制,机体通过DNA损伤信号传导,激活相应的修复途径,如MMR、BER、NER、SSER、DSER等,以保持基因组的稳定。近年研究发现,病原体感染可改变、破坏或操纵宿主DNA损伤修复途径,本文将综述细菌、病毒、寄生虫等病原体感染,对宿主DNA损伤修复机制的直接影响。
The integrity and stability of the genome is the basis for the survival of the body, abnormal genomic lead to tumors, immune defects and other diseases. DNA damage repair is the primary mechanism to maintain the integrity and stability of the nuclear genome. The body through the DNA damage signal transduction, activate the corresponding repair pathways, such as MMR, BER, NER, SSER, DSER, etc., to maintain the stability of the genome. In recent years, studies have found that pathogen infection can change, destroy or manipulate host DNA damage repair pathways. This article reviews the direct impact of bacterial, viral, parasitic and other pathogen infections on host DNA repair mechanisms.