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本文比较了洗必泰醋酸盐和洗必泰葡萄糖酸盐的杀精子效力和阻抑人精子穿透动情期牛宫颈粘液的作用。结果表明,两种形式的洗必泰盐类均有良好的杀精子效力和阻止精子穿透牛宫颈粘液的作用。应用Sander-Cramer杀精子试验法测定洗必泰醋酸盐和洗必泰葡萄糖酸盐的最低杀精子浓度分别为2.5mg/ml,5.0mg/ml。应用Cremer′s精子穿透法测定两种洗必泰盐类阻止人精子穿透牛宫颈粘液的作用很相似,当药物浓度是0.25%或0.5%时人精子穿透牛宫颈液的距离是0mm(对照是48mm)。
This article compares the effects of chlorhexidine acetate and chlorhexidine gluconate on the spermicidal efficacy and inhibition of human sperm penetration during estrus bovine cervical mucus. The results show that both forms of chlorhexidine salts have good spermicidal efficacy and prevent sperm from penetrating bovine cervical mucus. The minimum spermicidal concentrations of chlorhexidine acetate and chlorhexidine gluconate were determined to be 2.5 mg / ml and 5.0 mg / ml, respectively, using the Sander-Cramer spermicidal assay. The use of Cremer’s sperm penetration assay to determine the effect of two chlorhexidine salts on preventing human sperm from penetrating bovine cervix mucus is similar when the concentration of human serum is 0.25% or 0.5% (Control is 48mm).