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目的探讨和日联合运德素治疗慢性乙型肝炎的抗病毒疗效。方法随机获得156例慢性乙型肝炎患者,检测血清ALT,HBV DNA,HBeAg。I组80例接受和日与运德素联合治疗;II组76例单用运德素治疗。两组治疗前后均作生化指标及病毒学指标检测,以判定疗效标准(显效、有效、无效),进行对比观察、统计学比较和日联合运德素抗病毒疗效。结果治疗1年后ALT数值、HBV DNA阴转率、HBeAg血清转换率及总有效率经t检验和χ2检验,差异有统计学意义(t=11.26,P<0.01)。结论和日联合运德素治疗慢性乙型肝炎,抗病毒疗效较好,目前是治疗慢性乙型肝炎的有效方法。
Objective To investigate the anti-virus effect of combined treatment of Yun-te-Su with chronic hepatitis B. Methods A total of 156 patients with chronic hepatitis B were randomly selected to detect serum ALT, HBV DNA and HBeAg. 80 cases in group I received combined treatment with rotundin and 76 cases in group II with thalidomide alone. Before and after treatment both biochemical and virological indicators were detected in order to determine the efficacy criteria (markedly effective, ineffective), comparative observation, statistical comparison and anti-joint effect of Tetranychus. Results After 1 year of treatment, the ALT value, HBV DNA negative rate, HBeAg seroconversion rate and total effective rate were statistically significant (t = 11.26, P <0.01) by t test and χ2 test. Conclusion Combined with the United Kingdom Yun-Su treatment of chronic hepatitis B, antiviral efficacy is good, is currently an effective method of treatment of chronic hepatitis B.