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目的探讨免疫球蛋白A(IgA)肾病患者尿液血管紧张素原(AGT)活性与临床及肾脏组织损伤的关系。方法 55例肾穿刺活检确诊的IgA肾病患者,分别测定其尿液AGT含量,并与临床、病理指标相比较分析。结果尿液AGT含量与24 h尿蛋白定量、肾小球、肾小管及肾间质积分呈正相关。随着病理评分的加重、尿蛋白定量的增加,尿液AGT原逐渐升高(P<0.05)。结论 IgA肾病患者尿液AGT可以反映临床及肾脏组织损伤的程度,可作为临床评估IgA肾病病情的无创指标之一。
Objective To investigate the relationship between urinary angiotensinogen (AGT) activity and renal damage in patients with immunoglobulin A (IgA) nephropathy. Methods Fifty-five patients with IgA nephropathy diagnosed by renal biopsy were tested for urinary AGT levels and compared with clinical and pathological parameters. Results The urinary AGT content was positively correlated with 24 h urinary protein, glomerular, tubular and interstitial accumulation. With the increase of pathological score, the urinary protein increased gradually and the AGT of urine increased gradually (P <0.05). Conclusion AGT in urine of patients with IgA nephropathy can reflect the degree of clinical and renal tissue injury and can be used as one of the noninvasive indicators for clinical evaluation of IgA nephropathy.