哮喘的发病机制及防治一直是各国研究的热点 ,已取得了重大进展。关于哮喘的病因有许多学说 ,1983年Holtz man等提出呼吸道炎症学说 ,并指出与前列腺素 (PGS)、白三烯 (LTs)、血小板活化因子 (PAF)等有关 ,此学说已得到广泛认可。在众多细胞因子及炎症介质中 ,花生四烯酸的代谢 The pathogenesis and prevention of asthma have always been the focus of research in various countries and significant progress has been made. There are many theories about the etiology of asthma. In 1983, Holtz man et al. Proposed the theory of respiratory inflammation and pointed out that it has been widely accepted that it is related to prostaglandin (PGS), leukotrienes (LTs) and platelet activating factor (PAF). Metabolism of arachidonic acid in many cytokines and inflammatory mediators