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为探讨催产素(OT)在应激过程中的作用,采用侧脑室注射OT及抗OT血清,观察了50只大鼠游泳持续时间的变化。生理盐水组及正常兔血清组对大鼠无明显影响。脑室注射0.625、1.25、2.5及5.0ngOT,游泳持续时间缩短,且与给药剂量之间呈负相关(r=-0.950,P<0.05)。在注射抗OT血清2、4及8 μl后1～4d大鼠游冰持续时间均延长(P<0.01)。上述结果表明中枢内OT含量增多对游泳活动不利。
In order to investigate the role of oxytocin (OT) in the stress process, lateral ventricle injection of OT and anti-OT serum was used to observe the changes in swimming duration of 50 rats. The saline group and normal rabbit serum group had no significant effect on rats. Intraventricular injection of 0.625, 1.25, 2.5 and 5.0 ng OT, swimming duration was shortened, and was negatively correlated with the dose (r=-0.950, P<0.05). The duration of ice excretion in rats 1 to 4 days after injection of anti-OT serum 2, 4 and 8 μl was prolonged (P<0.01). The above results indicate that increased OT content in the central nervous system is detrimental to swimming activities.