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预存抗HLA抗体对移植器官的功能和存活有不利的影响,静脉注射免疫球蛋白是消除高致敏受者抗HLA抗体的方法之一。本文综述了静脉注射用免疫球蛋白的组成、免疫学机制、与抗HLA抗体的相互作用、以及其在高致敏受者肾移植急性排斥反应中的预防和治疗作用。
Pre-stored anti-HLA antibodies have an adverse effect on the function and survival of transplanted organs. Intravenous immunoglobulin is one of the methods to eliminate anti-HLA antibodies in highly sensitized recipients. This review summarizes the immunoglobulin composition, immunological mechanisms, interactions with anti-HLA antibodies, and its prophylactic and therapeutic effects in the acute rejection of highly sensitized recipients of renal allografts.