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目的通过不孕不育患者的染色体检查分析,观察遗传因素在不孕不育中的重要性。方法对575例患者的外周血进行培养,细胞收获,制片及G显带,必要时进行C显带检查,显微镜下进行核型分析。结果发现染色体异常52例,异常检出率为9.04%。异常核型中,常染色体数目或结构明显异常21例,检出率3.65%,性染色体数目或结构明显异常15例,检出率2.61%,其中嵌合体4例。同时,本资料中染色体多态现象16例,检出率2.78%,主要有9号染色体倒位,大、小Y等。结论染色体异常是导致患者不孕不育的重要病因,对于不孕不育夫妇,染色体分析必须作为常规的检测方法。
Objective To investigate the importance of genetic factors in infertility by chromosome analysis of infertility patients. Methods Peripheral blood samples of 575 patients were cultured, harvested, prepared and G-banded. C-banding was performed if necessary and karyotypes were analyzed under a microscope. The results showed that 52 cases of chromosomal abnormalities, the abnormal detection rate was 9.04%. Abnormal karyotype, the number of autosomal or structural abnormalities in 21 cases, the detection rate was 3.65%, the number of abnormal or significant number of chromosomes in 15 cases, the detection rate was 2.61%, of which 4 cases of chimerism. Meanwhile, 16 cases of chromosome polymorphism in this data, the detection rate of 2.78%, mainly chromosome 9 inversions, large and small Y and so on. Conclusion Chromosomal abnormalities are the main causes of infertility in patients. For infertile couples, chromosome analysis must be used as a routine test.