目的:探讨卵巢囊肿及囊肿核除术后对卵巢储备功能、妊娠率的影响。方法:选择双侧/单侧囊肿核除术及卵巢囊肿未达手术标准(但囊肿至少半年以上直径小于3cm,术前经穿刺证实为巧囊或单纯性囊肿)而直接行ART助孕的患者作为实验组,选其后第1个与其同龄的患者与之配对作为对照组,比较两组的卵巢储备情况、卵巢对促排卵药物的反应情况、着床和妊娠情况。结果:①双侧卵巢存在实验组(A1组)与对照组(A2组)比较,窦卵泡数、Gn支数、HCG日E2值、采卵日≥14mm卵泡数、采卵数、好胚数、冷冻数、移植数均有显著差异,而基础FSH值、GnRHa天数、着床率、流产率及妊娠率无差异。②一侧卵巢存在实验组(B1组)与对照组(B2组)比较,窦卵泡数、Gn支数、采卵日≥14mm卵泡数均有显著差异,而基础FSH值、GnRHa天数、HCG日E2值、好胚数、冷冻数、移植数、着床率、流产率及妊娠率无差异。③一侧卵巢存在囊肿未手术组(C1组)与对照组(C2组)比较,只在窦卵泡数上存在差异,而其余各项无统计学差异。结论:卵巢囊肿核除术以及囊肿存在本身会造成生殖功能部分下降,但生育能力未受明显影响。 Objective: To investigate the effect of ovarian cyst and cyst nuclear excision on ovarian reserve function and pregnancy rate. METHODS: Patients undergoing ART-assisted pregnancy were selected for both bilateral / unilateral cyst excision and ovarian cysts that did not meet the surgical criteria (however, cysts of at least 6 months in diameter were less than 3 cm in diameter, preoperatively confirmed as Qiao or simple cysts) As the experimental group, the first and the subsequent patients were selected as the control group. The ovarian reserve, ovarian response to ovulation induction, implantation and pregnancy were compared between the two groups. Results: (1) The number of antral follicles, Gn counts, E2 value on HCG day, the number of follicles of 14mm ovulation day≥14mm, the number of ovum and the number of good embryos in experimental group (A1) and control group (A2) , The number of frozen and the number of transplantation were significantly different, while the basis of FSH value, GnRHa days, implantation rate, abortion rate and pregnancy rate no difference. (2) There was a significant difference in the number of antral follicles, Gn count and the number of follicles of ≥ 14mm ovulation day in experimental group (B1 group) and control group (B2 group), while the basal FSH value, GnRHa days, HCG day E2 value, a good number of embryos, frozen number, the number of transplantation, implantation rate, abortion rate and pregnancy rate no difference. ③ ovarian cysts on one side of the non-surgical group (C1 group) compared with the control group (C2 group), only in the number of antral follicles there is a difference, while the rest no significant difference. Conclusion: Ovarian cyst nuclear removal and the presence of cyst itself may cause part of reproductive function decline, but fertility was not significantly affected.