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控制急性惊厥(包括SE)理想的药物应用起效快、持久和安全。在常用抗SE药物中无一安全符合以上指标,安定作为首选药物,其有效半衰期仅2—4小时,常需重复注射或持续静滴,但这样增加了呼吸抑制和低血压的危险性。劳拉西潘是一种更新的、有效的抗惊厥苯二氮(艹卓)类药物,半衰期13小时,一剂即能有效控制SE,故很少抑制呼吸。 作者对86例惊厥患儿进行了劳拉西潘和安定控制急性惊厥和SE疗效的对比观察,按单、双日进
The ideal drug control for acute convulsions (including SE) is fast, long lasting and safe. None of the commonly used anti-SE drugs meet the above criteria. Diazepam, as the drug of choice, has an effective half-life of only 2-4 hours, often requiring repeated injections or continuous intravenous drip, but this increases the risk of respiratory depression and hypotension. Laurasipan is a new and effective anticonvulsant benzodiazepine drug with a half-life of 13 hours. One dose is effective in controlling SE and therefore rarely suppresses breathing. The authors of 86 cases of convulsions in children with laxippan and stable control of acute seizures and SE comparison of efficacy, according to single,