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目的探讨纳米银创伤贴的皮肤刺激性刺激及变态反应。方法将纳米银创伤贴用于家兔背部完整或破损去毛区皮肤,观察其产生皮肤刺激性情况;采用致敏与激发接触纳米银创伤贴,观察豚鼠过敏情况。结果纳米银创伤贴未产生皮肤刺激性;反复致敏后无皮肤与全身变态反应。结论纳米银创伤贴是安全的新型外用贴剂。
Objective To investigate the skin irritation and allergy of nano silver wounds. Methods Nano-silver wounds were applied to the intact or damaged dehairing area on the back of rabbits and the skin irritation was observed. Sensitization and excitation were used to contact the nano-silver wounds to observe the allergy of guinea pigs. Results Nano-silver wound stickers did not produce skin irritation; repeated allergic skin and systemic allergies. Conclusion Nano silver wound stickers are safe new topical patches.