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目的:优选金茵清热口服液半仿生提取(SBE)液的醇沉浓度。方法:按比例分割法设立5个醇沉浓度30%、55%、61.25%、67.5%、80%进行平行试验。以绿原酸、栀子苷、丹酚酸B、总酚酸得率和干浸膏收率为指标进行考察,将各指标数据标准化处理,采用设定的加权系数进行综合评价得出综合评价值Y,根据Y值大小优选金茵清热口服液的SBE液醇沉浓度。结果:5个指标综合评价Y值由大到小的顺序为:30%>61.25%>55%>80%>67.5%。结论:结合口服液的澄明度问题与生产实际,以含醇量61.25%为最佳醇沉浓度。
Objective: To optimize the alcohol concentration of semi-bionic extraction (SBE) of Jin Yin Qingre oral liquid. Methods: According to the method of ratio division, five parallel experiments were set up to determine the alcohol concentration of 30%, 55%, 61.25%, 67.5% and 80% respectively. With chlorogenic acid, geniposide, salvianolic acid B, total phenolic acid yield and dry extract yield as an indicator to examine the standardization of each indicator data, using a set of weighted coefficients for comprehensive evaluation of the comprehensive evaluation The value of Y, according to the Y value of the size of the Jin Yin Qingre oral SBE liquid alcohol concentration. Results: The order of 5 indexes comprehensive evaluation of Y value was as follows: 30%> 61.25%> 55%> 80%> 67.5%. Conclusion: With the clarity of oral liquid and the actual production, alcohol content of 61.25% is the best alcohol concentration.