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目的 对血管紧张素原 (AGT)基因第二外显子M2 35T多态性与原发性高血压的关联性进行Meta分析。方法 以原发性高血压组和健康对照组基因型分布的OR值为统计量。全面检索相关文献 ,剔除不符合要求的文献 ,应用REVMAN 4 .1软件对各研究结果进行一致性检验和数据合并 ,并评估发表偏倚的影响。结果 10篇文献无明显异质性。共包括原发性高血压组患者 85 3例 ,健康对照组 835名 ,合并TT/ (MT +MM )OR =1.76 ,95 %CI :1.4 4～ 2 .16 ,P <0 .0 0 0 0 1,T/MOR =1.5 4 ,95 %CI:1.31～ 1.81,P <0 .0 0 0 0 1。结论 中国人 (汉族为主 )AGTM2 35T多态性的T等位基因和TT基因型与原发性高血压危险性增加有关联。
Objective To analyze the association between M2 35T polymorphism of angiotensinogen (AGT) gene exon 2 and essential hypertension. Methods The OR of the distribution of genotypes between the primary hypertension group and the healthy control group was taken as the statistic. Completely retrieve the relevant literature, remove unqualified literature, the use of REVMAN 4 .1 software consistency of the findings of the study and data consolidation, and to assess the impact of publication bias. Results 10 articles no obvious heterogeneity. A total of 853 patients with essential hypertension and 835 healthy controls were included, with a combined TT / (MT + MM) of 1.76 and a 95% CI of 1.4 4 to 2.16 (P <0.05) 1, T / MOR = 1.5 4, 95% CI: 1.31-1.81, P <0.00001. Conclusion The T allele and TT genotype of AGTM2 35T polymorphism in Chinese (predominately Han Chinese) are associated with the increased risk of essential hypertension.