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目的:研究祛膜颗粒对大鼠药物流产后子宫出血的治疗作用。方法:采用早孕大鼠灌胃给予米非司酮(12.50 mg/kg)和米索前列醇(0.12 mg/kg)造成不完全流产大鼠模型。观察祛膜颗粒对不完全流产大鼠模型的子宫出血量、凝血酶原时间(PT)、凝血酶时间(TT)、血浆纤维蛋白原(FIB)的影响;采用光学显微镜观察子宫内蜕膜、绒毛的残留情况;采用RM6240多道生理信号采集处理系统和JZJ01张力传感器记录大鼠离体子宫平滑肌的收缩活动。结果:祛膜颗粒能明显减少大鼠子宫出血量(P<0.05),缩短流产大鼠的PT、TT,增加FIB;祛膜颗粒能够促进子宫腔内的绒毛、蜕膜组织物排出。祛膜颗粒(0.1 g/L)与米非司酮和米索前列醇合用时,能明显提高大鼠离体子宫平滑肌收缩强度(P<0.05)。结论:祛膜颗粒对药物流产后的子宫出血有明显的止血作用,能增强子宫肌收缩,促进胚胎排出。
Objective: To study the therapeutic effect of Qufu Granule on uterine bleeding after drug abortion in rats. Methods: Rats with incomplete abortion were induced by intragastric administration of mifepristone (12.50 mg / kg) and misoprostol (0.12 mg / kg). To observe the effects of Qutu Granule on uterine bleeding, prothrombin time (PT), thrombin time (FTI) and fibrinogen (FIB) in incomplete abortion rat model; observe the changes of uterine decidual, Fluff residues; using RM6240 multi-channel physiological signal acquisition and processing system and JZJ01 tension sensor recording the contraction of isolated rat uterine smooth muscle. Result: Qumai Granule can significantly reduce the amount of uterine bleeding in rats (P <0.05), shorten the PT and TT of abortion rats, and increase FIB. Quchuang granules can promote the discharge of villus and decidua in uterine cavity. When used together with mifepristone and misoprostol, the Qushu Granule (0.1 g / L) significantly enhanced the contractile strength of isolated uterine smooth muscle in rats (P <0.05). Conclusion: Qu film particles on the bleeding after medical abortion uterine bleeding has obvious hemostatic effect, can enhance uterine muscle contraction and promote embryo discharge.