2例精神分裂症患者于用氯氮平治疗中合用催眠镇静药后并发昏迷,报道如下。 例1,男性,42a,因复发精神失常住院。入院检查无异常,诊断为精神分裂症。入院后即用氯氮平治疗,缓慢加至500mg/d,用该量d3,因未能控制其兴奋症状,晚上睡眠差而加服硝西泮5mg,次晨发现其昏迷不醒,呼之不应,压眶上神经无反应,口唇发绀,口内分泌物外溢,双肺痰鸣,双瞳孔直径2 Two patients with schizophrenia in the treatment of clozapine combined hypnotic sedatives and coma, reported as follows. Example 1, male, 42a, hospitalized for recurrent insomnia. No abnormal admission examination, diagnosis of schizophrenia. Clozapine treatment after admission, slowly added to 500mg / d, with the amount of d3, because of failure to control their excitement, poor sleep at night plus nitrazepam 5mg, the next morning found unconscious, calling Should not, the supraorbital nerve pressure response, cyanotic lips, oral secretions overflow, lung phlegm, double pupil diameter 2