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目的观察紫龙金片联合化疗治疗中晚期原发性肝癌与单纯化疗的临床效果。方法治疗组（紫龙金+化疗）16例，对照组（单纯化疗）16例。评定其疗效和免疫功能变化、生活质量和毒副作用。结果治疗组疗效好于对照组，病灶缓解率（CR+PR）为18.75%，免疫功能和生活质量明显改善，治疗后与对照组比较有显著差异（P<0.01)。治疗组的毒副作用明显低于对照组，经统计学处理有显著性差异（P<0.05）。结论紫龙金片对中晚期原发性肝癌患者有一定的疗效，免疫功能与生活质量明显改善。可能的机理是调节细胞免疫功能。“,” Objective:It is to observe curative effect of Zilongjin Tablet combined with chemotherapy and its synergism and detoxication on moderate and advanced of primary hepatic celular carcinomas Methods:The patients were divided randomly into two groups.The treated group(n=16)was treated chemotherapy plus Zilongjin Tablets;and the control group(n=16)treated with chemotherapy alone.Treatment effectiveness was measured with Complete remission and Partial remission(CR+PR)..Result:In the treatment group(16),clinical effect, ,improvement of life quality and immunologic function were better than those in control group(16)The toxic side-effects caused by chemotherapy in the treatment group were lower than that in the control group(p<0.05) .Conclusion: Zilongjin Tablet can enhance the therapeutic effect, improve life quality and reduce the side-effects of chemotherapy.One possible mechanism is the modulation of celular immune function.