作者研究了从银杏中提取的29种成分体外对人肝微粒体5种主要细胞色素P450(CYP)同工酶CYP1A2、CYP2C9、CYP2C19、CYP2D6和CYP3A活性的抑制作用。结果显示,三萜内酯类化合物银杏内酯A、B、C、J和白果内酯以及黄酮醇苷类成分对5种CYP同工酶活性仅有微弱的或无抑制作用;黄酮醇苷元山柰酚、槲皮素、芹菜苷元、4-羟基-甲基芹菜苷元、杨梅黄素和柽柳黄素对CYP1A2和CYP3A具有明显的抑制 The authors studied the inhibitory effects of 29 components extracted from ginkgo biloba on the activities of five major cytochrome P450 (CYP) isoenzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A in human liver microsomes. The results showed that the contents of ginkgolides A, B, C, J, and bilobalide and flavonol glycosides of the triterpene lactone compounds showed only slight or no inhibitory effects on the five CYP isozymes; flavonol aglycone Hawthorn phenol, quercetin, apigenin, 4-hydroxy-methyl celeryin, myricetin, and axanthin have significant inhibition on CYP1A2 and CYP3A