论文部分内容阅读
【目的】探讨冠心病（CHD）心力衰竭患者血清中骨保护素（OPG）和胰岛素样生长因子（IGF-Ⅰ）的水平变化及其意义。【方法】采用酶联免疫吸附检测法测定58例CHD慢性心力衰竭（CHF）患者（CHF组）和22例正常体检者（对照组）血清中OPG与IGF-Ⅰ水平，进行对照分析。【结果】CHF组患者血清OPG水平明显高于正常对照组，且随着心功能的恶化而明显增高（ P＜0．01），而血清IG F-Ⅰ水平明显低于正常对照组，且随着心功能的恶化而明显降低（ P＜0．01）。血清中OPG与IGF-Ⅰ水平呈负相关（ P ＜0．01）。【结论】OPG与IGF-Ⅰ共同参与了CHD的CHF的发生发展过程，二者的血清水平可以作为判断 CHF严重程度的指标。“,”[Objective]To explore the changes and significance of serum levels of osteoprotegerin (OPG ) and insulin-like growth factor-Ⅰ (IGF-Ⅰ) in patients with chronic heart failure(CHF) and coronary heart dis-ease(CHD) .[Methods]Enzyme-linked immunosorbent assay(ELISA) was used to determine serum levels of OPG and IGF-Ⅰ in 58 patients with CHF and CHD and 22 healthy subjects .Comparative analysis was taken .[Results]Serum OPG in CHF group was obviously higher than that in normal control groups ,and increased with the deterioration of cardiac function obviously ( P <0 .01) .Serum IGF-Ⅰin CHF group was obviously lower than that in normal control group ,and decreased with deterioration of cardiac function obviously ( P <0 .01) .Serum OPG was negatively related with IGF-Ⅰ( P<0 .01) .[Conclusion]OPG and IGF-Ⅰ conjointly participate in the occurrence and development of CHD and heart failure .Serum levels of OPG and IGF-Ⅰ can be used as the indicators for assessing the severity of heart failure .