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目的:探讨肠安合剂治疗腹泻型肠易激综合征(IBS-D)的药理机制。方法:通过母子分离+慢性束缚刺激的方法制作接近IBS-D临床表现的大鼠模型,将其分为正常组、模型组、肠安Ⅰ号组、肠安Ⅱ号组、痛泻要方组及得舒特组6个实验组,分别给予相应的干预措施,2周后测定各组大鼠血清中5-HT的含量,借助SPSS 20.0统计软件进行统计分析,评价各组大鼠的治疗效果。结果:肠安Ⅰ号组、肠安Ⅱ号组大鼠血清中的5-HT含量均比模型组大鼠降低,其差异具有统计学意义。结论:肠安合剂治疗IBS-D具有显著疗效,其作用机制可能是通过影响血清中5-HT的表达来实现的,同时也为中医药治疗IBS-D提供了一定的现代科学依据。
Objective: To investigate the pharmacological mechanism of Changan Mixture in treating diarrhea-predominant irritable bowel syndrome (IBS-D). Methods: Rat model of clinical manifestations close to IBS-D was made by mother-child separation and chronic restraint stimulation. The rats were divided into normal group, model group, Chang’an Ⅰ group, Changan Ⅱ group, Tongxieyaofang group And dextrose group 6 experimental groups were given the appropriate interventions, 2 weeks after the determination of serum 5-HT levels in rats, using SPSS 20.0 statistical software for statistical analysis to evaluate the treatment of rats in each group . Results: The contents of 5-HT in serum of rats in Chang’an I group and Chang’an Ⅱ group were lower than those in model group, and the difference was statistically significant. CONCLUSION: Herbicides can treat IBS-D with significant curative effect. Its mechanism may be through affecting the expression of 5-HT in serum, and it also provides certain modern scientific basis for TCM treatment of IBS-D.