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中药丹参是唇形科植物丹参(Salviamiltiorhiza Bge.)的干燥根,是一种具有活血、养血等多方面作用的中药。近年来通过大量中西结合的临床实践,说明丹参有止痛、镇静、抑菌、消炎、抗凝,促使纤维蛋白(元)裂解,其裂解产物有抑制血小板聚集的作用等。临床用于治疗冠心病、癫痫及脑炎后遗症等取得一定疗效。怎样理解一个药物有如此众多的作用与用途?与之相应丹参的化学成分也十分复杂,仅结构已知的成分已有十七种。本文论述重点在于通过比较分析的方法,以阐明丹参的成分与疗效或结构与活性的关系。其中有些结构的作用与用途已得到初步阐明。有些在临床上虽已肯定疗效但成
Salvia miltiorrhiza Bunge is a dried root of Salvia miltiorrhizae (Salvia miltiorhiza Bge.), a traditional Chinese medicine that has various functions such as promoting blood circulation and nourishing blood. In recent years, a large number of clinical practice of combining Chinese and Western medicine has shown that Salvia Miltiorrhiza has analgesic, sedative, antibacterial, anti-inflammatory and anticoagulant actions, promotes fibrin (RMB) cracking, and its lysates inhibit platelet aggregation. Clinical use for the treatment of coronary heart disease, epilepsy and encephalitis sequelae have achieved a certain effect. How do you understand that a drug has so many functions and uses? The chemical composition of Salvia miltiorrhiza is also very complicated. There are only 17 known structures. The focus of this article is on the method of comparative analysis to elucidate the relationship between composition and efficacy or structure and activity of Salvia miltiorrhiza. The role and use of some of these structures have been initially elucidated. Although some have clinically confirmed efficacy,