论文部分内容阅读
应用２×２析因实验设计将Ｗｉｓｔａｒ大鼠随机分为四组：Ｉ＋Ｓｅ＋、Ｉ＋Ｓｅ－、Ｉ－Ｓｅ＋、Ｉ－Ｓｅ－。观察了喂养１２周和３２周大鼠甲状腺重量，血清总Ｔ４、Ｔ３水平和血清碱性磷酸酶（ＡＫＰ）活性。结果表明，低碘组（Ｉ－Ｓｅ＋，Ｉ－Ｓｅ－）甲状腺重量明显增高，血清Ｔ４下降，Ｔ３变化不明显或代偿性升高。在低碘条件下低硒，１２周时甲状腺重量增加快于低碘加硒组，但是在３２周时，甲状腺重量虽然继续增加，其速度却明显慢于低碘加硒组。血清ＡＫＰ无论１２周还是３２周时，酶活性明显下降仅发生在低碘同时伴有低硒时（Ｉ－Ｓｅ－），当低碘加硒时（Ｉ－Ｓｅ＋），ＡＫＰ活性明显增加且与加碘组（Ｉ＋Ｓｅ＋，Ｉ＋Ｓｅ－）无显著性差别。上述结果提示，缺碘是造成甲状腺肿大的主要原因，缺硒１２周时具有加重甲状腺肿大的辅助作用。
Wistar rats were randomly divided into four groups with 2 × 2 factorial experimental design: I + Se +, I + Se-, I-Se +, I-Se-. Thyroid weights, serum total T4 and T3 levels, and serum alkaline phosphatase (AKP) activity were observed at 12 and 32 weeks of feeding. The results showed that the weight of thyroid in I-Se + and I-Se- was significantly increased, serum T4 decreased, and T3 changed insignificantly or compensatoryly. Under the low iodine condition, the thyroid weight increased faster at 12 weeks than that of the iodine and selenium group. However, at 32 weeks, the thyroid weight continued to increase at a slower rate than that of the iodine and selenium group. Serum AKP at 12 weeks or 32 weeks, the enzyme activity decreased significantly only in the low iodine accompanied by low selenium (I-Se-), when low iodine selenium (I-Se +), AKP activity was significantly increased and Iodine group (I + Se +, I + Se-) no significant difference. The above results suggest that iodine deficiency is the main cause of goiter, selenium deficiency at 12 weeks with the role of increased goiter.