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目的 研究补肾活血方治疗更年期综合症的作用机制。方法 采用雌性SD大鼠更年期模型,观察补肾活血方对更年期SD大鼠子宫重量指数、阴道涂片的影响以及对更年期SD大鼠血清卵泡刺激素(FSH)含量的影响。结果 (1 )子宫重量指数与补肾活血方的剂量呈依赖性增加。(2 )更年期SD大鼠阴道上皮细胞出现不同程度的角化现象。(3)补肾活血方能明显降低更年期SD大鼠血清FSH的含量。结论 补肾活血方能降低更年期大鼠血清FSH的含量,有效改善更年期综合症。
Objective To study the mechanism of Bushen Huoxue Prescription in the treatment of climacteric syndrome. Methods Female SD rat climacteric model was used to observe the effect of Bushen Huoxue Fang on uterine weight index and vaginal smear of menopausal SD rats and the effect of serum follicle stimulating hormone (FSH) content on climacteric SD rats. Results (1) The uterine weight index and the dose of Bushen Huoxue decoction showed a dependent increase. (2) There were different degrees of keratinization in vaginal epithelial cells of menopausal SD rats. (3) Bushen Huoxue can significantly reduce serum FSH levels in menopausal SD rats. Conclusion Bushen Huoxue Decoction can reduce the serum FSH levels in climacteric rats and effectively improve menopausal syndrome.