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既往认为十二指肠溃疡性疼痛是因溃疡的十二指肠粘膜接触胃酸而引起,倘若如此,疼痛应与十二指肠内酸度有关。十二指肠内pH不单取决于进入其内的胃液的pH,而且有赖于胃、十二指肠排空率及进入其内的碱性液分泌率。研究提示胃内pH与十二指肠内pH之间并无关联。十二指肠溃疡性疼痛与胃内低pH的关系是临床经典提法,但问题是胃窦部酸浓度要达到何种程度才会使十二指肠溃疡患者产生疼痛。
In the past that duodenal ulcer pain is due to gastric ulcer mucosal contact with gastric acid caused, if so, the pain should be related to intraduodenal acidity. The intraduodenal pH depends not only on the pH of the gastric juice entering it, but also on the gastric and duodenal emptying rates and the rate of alkaline fluid excretion into it. The study suggests there is no correlation between intragastric pH and intraduodenal pH. The relationship between duodenal ulcer pain and low pH in the stomach is a classic clinical formulation, but the question is, to what extent should the gastric acid concentration in the antrum go to cause pain in patients with duodenal ulcers.