目的:探讨神经节苷脂联合高压氧治疗新生儿缺血缺氧性脑病的临床疗效。方法:该次研究选择该院在2013年7月至2016年7月期间收治的60例缺血缺氧性脑病患儿,按照随机原则分为对照组(30例)和观察组(30例),观察组给予神经节苷脂联合高压氧治疗,对照组进行吸氧、保温等常规治疗,对比分析两组患儿的治疗有效率和智力发育指数。结果:观察组总有效率为96.67%高于对照组总有效率(73.33%),差异有统计学意义(P<0.05);观察组患儿智力发育指数为(95.89±11.10),明显高于对照组的(86.57±10.97),差异有统计学意义(P<0.05)。结论:神经节苷脂联合高压氧能有效治疗新生儿缺血缺氧性脑病,治疗中患儿意识恢复快,惊厥较易控制,提高了患儿的生存质量,安全有效,值得临床推广。 Objective: To investigate the clinical effect of ganglioside plus hyperbaric oxygen on neonatal hypoxic-ischemic encephalopathy. Methods: Sixty children with hypoxic-ischemic encephalopathy admitted to our hospital from July 2013 to July 2016 were selected and randomly divided into control group (30 cases) and observation group (30 cases) . The observation group was treated with ganglioside combined with hyperbaric oxygen. The control group was given conventional therapy such as oxygen inhalation and thermal insulation. The therapeutic efficiency and intellectual development index of the two groups were compared. Results: The total effective rate in the observation group was 96.67%, which was higher than that in the control group (73.33%), the difference was statistically significant (P <0.05). The mental development index in the observation group was (95.89 ± 11.10) The control group (86.57 ± 10.97), the difference was statistically significant (P <0.05). CONCLUSION: Ganglioside combined with hyperbaric oxygen can effectively treat neonatal hypoxic-ischemic encephalopathy. The treatment of children with rapid recovery of consciousness, convulsions easier to control, improve the quality of life in children, safe and effective, worthy of clinical promotion.