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目的:以枳壳为模型药物,从信息熵的角度计算指纹图谱的相似度以研究中药的道地性。方法:采用高效液相色谱法分析不同来源枳壳药材指纹图谱;利用信息熵计算指纹图谱相似度识别枳壳道地性并与传统方法进行比较。结果:与传统方法相比较,利用信息熵计算指纹图谱相似度的方法能明显提高对“江枳壳”药材道地性的识别效果。结论:该法为枳壳道地性识别提供了科学的参考依据。
OBJECTIVE: To study the similarity of fingerprints with Citrus aurantium as a model drug to study the authenticity of traditional Chinese medicine. Methods: Fingerprints of Fructus Aurantii from different sources were analyzed by high performance liquid chromatography (HPLC). The similarity of fingerprint was calculated by using information entropy to identify the authenticity of Fructus Aurantii and compare with traditional methods. Results: Compared with the traditional methods, the similarity of fingerprints can be significantly improved by using the entropy of information entropy. Conclusion: This method provides a scientific reference for the identification of native aurantium.