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在药物动力学分析中,建立数学模型、导出算式并确定有关参数等,是至关重要的研究环节。对经典线性及非线性模型,本刊已陆续有多篇介绍。鉴于线性乳突型模型虽仍在广泛应用,但有其局限性;而正在发展中的生理模型,因将隔室概念与解剖生理概念直接联系起来,可能更有益于实际应用及理论探讨,值得引起重视。本期我们组织了2篇综述,主要从不同角度阐述生理模型的有关基本概念;下期将刊出有关译文,全面介绍应用方面的进展。希望能对读者了解国外生理模型最新研究的全貌有所裨益。
In pharmacokinetic analysis, the establishment of mathematical models, derive formulas and determine the parameters, etc., is a crucial research link. For classical linear and nonlinear models, we have introduced many articles in succession. Although the linear mastoid model is still widely used, it has its limitations. However, the developing physiological model may be more beneficial to the practical application and theoretical discussion because of the direct connection between the concept of compartment and the anatomic physiology. It is worth Caused attention. This issue we organized 2 reviews, mainly from different perspectives on the physiological model of the basic concepts related to the next issue will be published translation, a comprehensive introduction to the application of progress. It is hoped that it will be helpful for readers to understand the latest research on physiological models abroad.