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本文应用PCR－RFLP方法对８４例肝癌患者和１４４例健康对照的引起CYP２D６酶活性完全缺乏的A型和B型突变，以及３种引起CYP２D６酶活性降低的多态性（C１８８→T、C２９３８→T和G４２６８→C）进行了检测，旨在探讨CYP２D６基因的多态性与肝癌的关系。１材料与方法１．１材料
In this study, PCR-RFLP was used to detect the type A and type B mutations that completely lacked CYP2D6 activity in 84 patients with hepatocellular carcinoma and 144 healthy controls, and three polymorphisms (C188 → T, C2938 → T and G4268 → C) were detected in order to investigate the CYP2D6 gene polymorphism and liver cancer. 1 Materials and Methods 1.1 Materials