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目的探讨盆腔淋巴结人类乳头瘤病毒基因(HPV-DNA)检出率与早期宫颈癌临床转移的关系。方法对62例宫颈癌患者原发部位肿瘤组织和盆腔淋巴结组织的HPV-DNA区基因序列进行测定,同时分析其阳性率与早期宫颈癌转移之间的关系。结果 62例盆腔淋巴结当中的HPV-DNA检出率为51.6%(32/62),26例淋巴结转移的组织当中HPV-DNA检出率为84.6%(22/26),36例检查没有淋巴结转移的盆腔淋巴结HPV-DNA检出率为27.8%(10/36),有无淋巴结转移患者盆腔淋巴结HPV-DNA检出率比较差异具有统计学意义(P<0.05)。另外,阳性淋巴结当中的闭孔、髂外以及髂内的淋巴结占90%以上。结论盆腔淋巴结的HPV-DNA检出阳性属于一个具有重要意义的淋巴结转移预测因子,其中最为关键的前哨淋巴结包括有闭孔、髂外以及髂内的淋巴结。
Objective To investigate the relationship between the detection rate of human papillomavirus (HPV-DNA) in pelvic lymph nodes and the clinical metastasis of early cervical cancer. Methods 62 cases of cervical cancer patients with primary tumor tissue and pelvic lymph node tissue HPV-DNA region sequence was determined at the same time its positive rate and the relationship between early cervical cancer metastasis. Results The detection rate of HPV-DNA in 62 cases of pelvic lymph nodes was 51.6% (32/62). The HPV-DNA detection rate was 84.6% (22/26) in 26 cases of lymph node metastasis, and 36 cases had no lymph node metastasis The detection rate of HPV-DNA in pelvic lymph nodes was 27.8% (10/36). There was significant difference in the detection rate of HPV-DNA in pelvic lymph nodes with or without lymph node metastasis (P <0.05). In addition, the positive lymph nodes among the obturator, external iliac and internal iliac lymph nodes accounted for more than 90%. Conclusions Positive HPV-DNA detection in pelvic lymph nodes belongs to a significant predictor of lymph node metastasis. Among them, the most critical sentinel lymph nodes include closed-cell, external iliac and internal iliac lymph nodes.