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目的:探讨氨甲苯酸联合维生素E治疗宫内节育器(IUD)致子宫异常出血的临床疗效。方法:将119例IUD致子宫异常出血患者随机分为观察组和对照组,观察组给予口服氨甲苯酸片联合维生素E胶囊,对照组给予口服宫血宁胶囊,观察用药后的治愈率。结果:观察组(n=61)治疗子宫异常出血总有效率100.00%,其中治愈50例(81.97%)、显效11例(18.03%)。对照组(n=58)总有效率为77.59%,其中治愈24例(41.38%)、显效21例(36.20%)、无效13例(22.41%)。组间总有效率差异有统计学意义(P<0.005)。对患者经量增多、经期延长、经间出血率的治疗效果,组间差异也有统计学意义(P<0.05)。结论:氨甲苯酸联合维生素E治疗IUD所致的子宫异常出血疗效确切,具有一定的临床推广价值。
Objective: To investigate the clinical efficacy of aminomethyl benzoate combined with vitamin E in the treatment of abnormal uterine bleeding caused by IUD. Methods: One hundred and nineteen patients with abnormal uterine bleeding caused by IUD were randomly divided into observation group and control group. Oral methotrexate combined with vitamin E capsule was given to the observation group. Oral Gongxuening capsule was given to the control group. The cure rate after treatment was observed. Results: The total effective rate of abnormal uterine bleeding in observation group (n = 61) was 100.00%, of which 50 cases were cured (81.97%) and 11 cases (18.03%) were markedly cured. The total effective rate of the control group (n = 58) was 77.59%, of which 24 cases were cured (41.38%), 21 cases (36.20%) were effective and 13 cases (22.41%) were ineffective. The total effective rate between the groups was statistically significant (P <0.005). There was also a significant difference between the two groups (P <0.05) on the treatment effect of patients with increased amount of menstruation, prolonged menstrual flow and bleeding rate. Conclusion: Methotoma acid combined with vitamin E in the treatment of abnormal uterine bleeding caused by IUD has definite clinical value.