Aclacinomycin A的大鼠亚急性毒性研究

来源 :抗生素 | 被引量 : 0次 | 上传用户:ruyudeishui
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
本文报道大白鼠经30天腹腔注射Acla-cinomycin A(ACM-A)后一般毒性症状、血液生化及病理检查等方面的变化,共分为四个剂量组 (1)ACM—A 3mg/kg 组大鼠 于给药5天食欲明显减退、体重减轻、皮毛蓬松、活动减少,眶周血痴,便血或肛门不洁,呼吸困难,10天后全部动物死亡。解剖所见血性腹水,肝、十二指肠、胃、腹膜粘连,肺轻度瘀血;病理检查主要可见心肌纤维灶性玻璃样变性及水肿,脾脏红髓及脾小体淋巴细胞减少,睾丸曲精管内精原细胞减少。 (2)CAM-A1.5mg/kg组动物体重增长略慢,有1例19天死亡,外用血液测定发现白 This article reports the changes of general toxicity, blood biochemistry and pathology after Acla-cinomycin A (ACM-A) administration in rats for 30 days. The ACM-A 3mg / kg group is divided into four groups: Rats in the administration of 5 days significantly reduced appetite, weight loss, fluffy fur, reduced activity, periorbital blood stool, blood in the stool or anus, breathing difficulties, all animals died after 10 days. Anatomical findings of bloody ascites, liver, duodenum, stomach, peritoneal adhesions, mild stasis of the lung; pathological examination showed mainly focal fibrosis of myocardial fibrosis and edema, splenic red pulp and spleen lymphopenia, testis Trichostatin spermatogonial cells decreased. (2) The weight gain of CAM-A1.5mg / kg group was slightly slower, one case died on the 19th day, and the external blood test found that the white
其他文献
巯甲丙脯酸(Captopril,以下简称CPT,又称SQ_(14225))系非肽类化合物,是一种血管紧张素Ⅰ转化酶的竞争性抑制剂,属新型口服高效的扩血管降压药,1977年问世以来,国内外已普遍
本文介绍我所新抗室试制的Aclacinom-y cin A(ACM-A)体外、体内抗肿瘤活性,并与进口样品进行了比较。在体外,用~3H-TdR、~3HUR掺入试验法表明ACM-A在浓度为3.25~1.25μ/ml时
稽查分局现有干部职工52人,大部分都是年轻人,35岁以下青年占全分局人数的90%,平均年龄31岁,均为大专以上学历。几年来,这些年轻团员青年们在特区的税收事业上,用青春和热血,
能兼治多种蠕虫病(蛔虫、钩虫、鞭虫和粪类圆线虫等)的广谱药并不多。丙硫咪唑(albendazole,下简称ALB)是苯并咪唑(benzimidazole carbamates)类的新化合物,它对多种蠕虫感
Objective To investigate the age-long claim by the locales that the food thickener,M.urens seed,has antispermatogenic,hence,antifertility effects in man.Methods
“费改税”势在必行本刊编辑部朱基总理把新一届政府要做的几件事概括为“一个确保、三个到位、五项改革。”在五项改革之一的“进一步完善财税制度改革”中,“费改税”便是
其实与上司的交往,就像是一场艰难的踩钢丝表演,冷静、协调与平衡才是成功的关键。这也是职场最重要的生存法则。 In fact, the interaction with the boss, like a tough s
根据试验结果作者认为,乙基西梭霉素(netilmicin)的毒性比妥布霉素(tobramycin)低,而后者的毒性又比庆大霉素低。Lerner等人在254例严重革兰氏阴性杆菌感染病例,应用妥布霉
Atkinsiella hamanaensis sp. nov.a marine mastigomycete isolated from ova o?the mangrove crab, scylla serrata (Forsskal). is described and illustrare“ The fung
本文改良建立羊水总胆碱酯酶活性比色测定法。此法简便,适于推广;反应颜色可稳定90分钟;羊水样品在-4℃或-20℃至少可保存4个月,其总胆碱酯酶活性稳定不变;重复测定13管的变