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本文报道大白鼠经30天腹腔注射Acla-cinomycin A(ACM-A)后一般毒性症状、血液生化及病理检查等方面的变化,共分为四个剂量组 (1)ACM—A 3mg/kg 组大鼠 于给药5天食欲明显减退、体重减轻、皮毛蓬松、活动减少,眶周血痴,便血或肛门不洁,呼吸困难,10天后全部动物死亡。解剖所见血性腹水,肝、十二指肠、胃、腹膜粘连,肺轻度瘀血;病理检查主要可见心肌纤维灶性玻璃样变性及水肿,脾脏红髓及脾小体淋巴细胞减少,睾丸曲精管内精原细胞减少。 (2)CAM-A1.5mg/kg组动物体重增长略慢,有1例19天死亡,外用血液测定发现白
This article reports the changes of general toxicity, blood biochemistry and pathology after Acla-cinomycin A (ACM-A) administration in rats for 30 days. The ACM-A 3mg / kg group is divided into four groups: Rats in the administration of 5 days significantly reduced appetite, weight loss, fluffy fur, reduced activity, periorbital blood stool, blood in the stool or anus, breathing difficulties, all animals died after 10 days. Anatomical findings of bloody ascites, liver, duodenum, stomach, peritoneal adhesions, mild stasis of the lung; pathological examination showed mainly focal fibrosis of myocardial fibrosis and edema, splenic red pulp and spleen lymphopenia, testis Trichostatin spermatogonial cells decreased. (2) The weight gain of CAM-A1.5mg / kg group was slightly slower, one case died on the 19th day, and the external blood test found that the white