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慢性粒细胞白血病(CML)在儿童中比较罕见,和成人CML相比在生物学和临床表现方面均有差异。儿童CML的特征为白细胞计数明显升高和巨脾。酪氨酸激酶抑制剂(TKI)伊马替尼等在儿童患者中表现出良好的疗效和安全性,是儿童慢性期CML治疗的一线选择。本文将儿童与成人CML的临床特点、儿童CML治疗进展及未来面临的问题做一综述。
Chronic myeloid leukemia (CML) is rare in children and differs in both biological and clinical manifestations compared to adult CML. CML in children is characterized by a marked increase in white blood cell count and splenomegaly. Tyrosine kinase inhibitor (TKI) imatinib and other children in patients with good performance and safety, is a first-line treatment of chronic CML in children. This article reviews the clinical features of children and adults with CML, the progress of children with CML and the problems they will face in the future.